Stabilized fc polypeptides with reduced effector function...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 16/46 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2750533

A method of producing Fc-containing polypeptides, such as antibodies, having stabilized Fc regions is provided, together with stabilized Fc polypeptides produced according to these methods as well as methods of using such antibodies as therapeutics.

La présente invention concerne un procédé de production de polypeptides contenant Fc, tels que des anticorps, ayant des régions Fc stabilisées. L'invention propose également des polypeptides Fc stabilisés produits selon ces procédés ainsi que des procédés d'utilisation de ces anticorps en tant que produits thérapeutiques.

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