Stabilized fluorescent rare earth labels and labeled...

Details Stabilized fluorescent rare earth labels and labeled... Stabilized fluorescent rare earth labels and labeled...

G - Physics

01

N

167/43

G01N 33/533 (2006.01) G01N 33/52 (2006.01) G01N 33/58 (2006.01)

Patent

CA 1254131

-0- STABILIZED FLUORESCENT RARE EARTH LABELS AND LABELED PHYSIOLOGICALLY REACTIVE SPECIES Abstract of the Disclosure Improved fluorescent labels comprise a fluorescent rare earth chelate incorporated into a polymeric particle derived from a loadable latex. The polymer comprises: (a) from about 50 to about 96 weight percent of recurring units derived from a hydrophobic ethylenically unsaturated polymerizable monomer, (b) from about 2 to about 30 weight percent of recurring units derived from a nonionic hydro- philic ethylenically unsaturated polymerizable monomer, and (c) from about 2 to about 20 weight percent of recurring units derived from an anionic ethylenically unsaturated polymerizable monomer containing at least one solubilizing group. The labels of this invention have greatly improved stability in aqueous solutions and do not prematurely agglomerate during storage. They can be attached to any of a variety of physiologically reactive species to provide labeled species, and are particularly use- ful in specific binding assays.

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