Stabilized formulations comprising amlodipine maleate

Details Stabilized formulations comprising amlodipine maleate Stabilized formulations comprising amlodipine maleate

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/375 (2006.01) A61K 31/4422 (2006.01) A61K 33/42 (2006.01) A61K 45/08 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2390636

The present invention is concerned with means for stabilising amlodipine maleate of the formula: (see above formula) to prevent the formation of unwanted Michael adduct and with stabilised pharmaceutical compositions obtained thereby. For stabilising amlodipine maleate, an acid (such as maleic acid, phosphoric acid, ascorbic acid or sorbic acid) having a pK1 greater than 1.5 is employed.

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