Stabilized freeze-dried formulation for cephalosporin...

Details Stabilized freeze-dried formulation for cephalosporin... Stabilized freeze-dried formulation for cephalosporin...

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 31/546 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2585296

The present invention relates to a freeze-dried formulation for cephalosporin derivatives having increased stability, a solution for obtaining and a method for preparing such a formulation, as well as the use of certain compounds for stabilizing cephalosporin derivatives in freeze-dried formulations. The compounds preferably used as stabilizers according to the invention are mannitol, trehalose, and PVP.

L'invention concerne une forme lyophilisée de dérivés de céphalosporine présentant une stabilité accrue, une solution permettant d'obtenir une telle forme, et un procédé permettant de préparer une telle forme, ainsi que l'utilisation de certains composés pour stabiliser les dérivés de céphalosporine dans des formes lyophilisées. Les composés utilisés comme stabilisateurs selon l'invention sont de préférence le mannitol, le tréhalose, et le PVP.

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