Stabilized hemoglobin solutions

Details Stabilized hemoglobin solutions Stabilized hemoglobin solutions

A - Human Necessities

61

K

A61K 38/42 (2006.01) A61J 1/10 (2006.01) B65D 30/02 (2006.01) A01N 1/00 (2006.01)

Patent

CA 2444590

A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.

L'invention concerne un système de contenant souple imperméable à l'oxygène servant à contenir une solution d'hémoglobine. Le système comprend un film multicouche présentant au moins une couche de contact avec le produit; une couche barrière d'oxygène et d'humidité et une couche externe. Le système de contenant souple comprend également un orifice d'interface servant à remplir le contenant souple avec la solution d'hémoglobine et à distribuer ladite solution. La solution d'hémoglobine comprend une solution pyridoxylée, réticulée, sensiblement exempte de stroma et de tétramères, qui contient des préservatifs tels que l'acide ascorbique, la glycine et la dextrose.

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