C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/117 (2010.01) A61K 31/7105 (2006.01) A61K 31/7125 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2692161
The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
L'invention concerne l'utilisation thérapeutique de nouveaux oligoribonucléotides stabilisés en tant qu'agents immunomodulateurs pour des applications de thérapie immunitaire. L'invention concerne notamment de nouveaux oligoribonucléotides à base d'ARN qui présentent une meilleure stabilité de nucléase et RNase et qui ont une activité immunomodulatrice par le biais de TLR7 et/ou TLR8.
Agrawal Sudhir
Bhagat Lakshmi
Kandimalla Ekambar R.
Lan Tao
Wang Daqing
Benoit & Cote Associes Inc.
Idera Pharmaceuticals Inc.
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