A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 37/04 (2006.01) C07H 21/02 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2648585
The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
L'invention concerne l'utilisation thérapeutique d'oligoribonucléotides stabilisés comme agents immunomodulateurs pour applications immunothérapeutiques. Plus particulièrement, l'invention concerne des oligoribonucléotides à base d'ARN présentant une stabilité nucléasique et RNasique accrue et une activité immunomodulatrice à travers TLR7 et/ou TLR8.
Agrawal Sudhir
Kandimalla Ekambar R.
Lan Tao
Li Yukui
Putta Mallikarjuna Reddy
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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