Stabilized interface for iontophoresis

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 9/70 (2006.01) A61K 47/42 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2171909

An interface is formed by incorporating (1) a mixture comprising a water-soluble protein and a drug into a matrix, or preferably (2) a mixture comprising a water-soluble protein and a drug to a porous matrix coated with a cationic surfactant or other ionic surfactant. The coating amount of the ionic surfactant is about 0.1 to 50 µg, and the content of the water- soluble protein is about 0.1 to 1,500 µg, each per 1 cm2 of the matrix. The water-soluble protein includes an albumin and the drug includes a physiologically active peptide or protein, for example. The use of the stabilized interface inhibits decrease of the drug retaining amount, and insures an effective transdermal drug delivery with high a repeatability and accuracy.

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