Stabilized liquid anti-rsv antibody formulations

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 39/42 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2489632

The present invention provides liquid formulations of SYNAGIS® or an antigen~binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.

La présente invention concerne des préparations liquides de SYNAGIS?®¿ ou d'un fragment de liaison antigène qui se fixe de manière immunospécifique à un antigène du virus respiratoire syncytial (VRS), lesdites préparations présentant une certaine stabilité, des niveaux d'agrégation faibles, voire indétectables, et très peu à pas de perte des activités biologiques du SYNAGIS?®¿ ou d'un fragment de liaison antigène, même au cours de longues périodes de stockage. La présente invention concerne notamment des préparations liquides constituées de SYNAGIS?®¿ ou d'un fragment de liaison antigène qui se fixe de manière immunospécifique à un antigène du VRS, lesdites préparations étant sensiblement exemptes de tensio-actifs, de sels inorganiques et/ou d'autres excipients communs. De plus, l'invention concerne une méthode de prévention, de traitement ou d'atténuation de symptômes associés à l'infection par le VRS à l'aide de préparations liquides selon la présente invention.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Stabilized liquid anti-rsv antibody formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized liquid anti-rsv antibody formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized liquid anti-rsv antibody formulations will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1359138

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.