A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/20 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2477857
Stabilized liquid interleukin-2 containing pharmaceutical compositions are provided. The compositions comprise an amino acid base, which serves as the primary stabilizing agent of the polypeptide, and an acid and/or its salt form to buffer the solution within an acceptable pH range for stability of the interleukin-2. The compositions are near isotonic. Methods for increasing stability of interleukin-2 in a liquid pharmaceutical composition and for increasing storage stability of such a pharmaceutical composition are also provided.
Chen Bao-Lu
Hora Maninder
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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