Stabilized microbubble compositions for ultrasound

Details Stabilized microbubble compositions for ultrasound Stabilized microbubble compositions for ultrasound

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/22 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2164813

A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760 - x) mm Hg at 37 °C, where x is the vapor pressure of the second gas at 37 °C, and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37 °C; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75 % of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.

Préparation formée d'une pluralité de microbulles comportant un premier gaz et un second gaz entourés d'une membrane telle qu'un tensioactif, le premier gaz et le second gaz étant présents selon un rapport molaire compris entre environ 1:100 et environ 1000:1, le premier gaz présentant une pression de vapeur d'au moins environ (760 - X) mm Hg à 37 DEG C, où X représente la pression de vapeur du second gaz à 37 DEG C, et la pression de vapeur de chacun des premier et second gaz étant supérieure à environ 75 mm Hg à 37 DEG C; procédés de préparation de compositions à microbulles, et notamment de compositions dont le diamètre moyen diminue d'une première valeur à une seconde valeur inférieure à environ 75 % de la première, lesdites compositions étant stabilisées lorsqu'elles présentent le second diamètre moyen; procédés et trousses de préparation de microbulles; et procédés d'utilisation de ces microbulles comme agents de contraste.

Affiliated with

Also associated with

Rating

Stabilized microbubble compositions for ultrasound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized microbubble compositions for ultrasound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized microbubble compositions for ultrasound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1769268