Stabilized milnacipran formulation

A - Human Necessities – 61 – K

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Details

A61K 31/165 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 47/04 (2006.01) A61K 47/10 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2611724

It is intended to provide a milnacipran formulation which is more stable than a conventionally known milnacipran formulation, and a method of stabilizing a milnacipran formulation. The object could be achieved by using a milnacipran- containing composition in which milnacipran or a salt thereof is allowed to exist in a porous carrier, packing a powder containing milnacipran or a salt thereof in an HPMC capsule, or combining an additive which does not cause an interaction with milnacipran with time.

La présente invention décrit une formule de milnacipran qui est plus stable que les formules conventionnelles de milnacipran, ainsi qu'une méthode de stabilisation d'une formule de milnacipran. L'objet de l'invention est réalisé en utilisant une préparation contenant du milnacipran dans laquelle le milnacipran ou un sel de ce composé est inclus dans un vecteur poreux, en introduisant une poudre contenant le milnacipran ou un sel de ce dérivé dans une gélule de HPMC, ou en introduisant un adjuvant n~interagissant pas avec le milnacipran au cours du temps.

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