C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 48/00 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2498918
The present invention relates to a method to condense DNA without any high- molecular-weight condensing agents by condensing plasmid DNA with a divalent cation and a lyophilizable alcohol. The invention also relates to an aqueous composition which includes condensed plasmid DNA and a carrier such as a lyophilizable, water-miscible alcohol and a divalent cation.
La présente invention concerne un procédé permettant de condenser l'ADN sans agent de condensation de masse moléculaire élevée, par condensation de l'ADN plasmidique avec un cation divalent et un alcool lyophilisable. L'invention concerne également une composition aqueuse comprenant de l'ADN plasmidique et un vecteur tel qu'un alcool lyophilisable et miscible dans l'eau et un cation divalent.
Adami Roger Christopher
Gatlin Larry Alan
Knight Jefferson David
Pfizer Products Inc.
Sim & Mcburney
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