Stabilized natural cannabinoid formulation

Details Stabilized natural cannabinoid formulation Stabilized natural cannabinoid formulation

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 31/352 (2006.01)

Patent

CA 2480270

The present invention is related to a pharmaceutical composition comprising a natural cannabinoid compound, e.g..DELTA.9-tetrahydrocannabinol, and a glass of a sugar, sugar alcohol, mixture of sugars or mixture of sugar alcohols, characterized in that the natural cannabinoid compound is incorporated in the sugar glass as a monomolecular encapsulation without formation of a guest-host complex. The invention further relates to a method for the preparation of said pharmaceutical composition in the form of a sugar glass by freeze drying, spray drying, vacuum drying, or critical drying of a stable mixture containing the natural cannabinoid compound and a sugar or a mixture of sugars.

La présente invention concerne une composition pharmaceutique comprenant un composé à base de cannabinoïde naturel tel que le ??9¿-tétrahydrocannabinol, et de sucre cuit, d'alcool de sucre, de mélange de sucres, ou de mélange d'alcools de sucre. Cette composition est caractérisée en ce que le composé à base de cannabinoïde naturel est intégré au sucre cuit sous forme d'une encapsulation monomoléculaire sans formation de complexe invité-hôte. L'invention concerne en outre un procédé pour l'élaboration de cette composition sous forme de sucre cuit par séchage au froid, par pulvérisation, par évaporation sous vide ou séchage critique d'un mélange stable contenant le composé à base de cannabinoïde naturel et un sucre ou un mélange de sucres.

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