Stabilized nitric oxide-primary amine complexes useful as...

Details Stabilized nitric oxide-primary amine complexes useful as... Stabilized nitric oxide-primary amine complexes useful as...

A - Human Necessities

61

K

A61K 31/04 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/14 (2006.01) A61K 31/655 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2046910

A method of treating cardiovascular disorders in a mammal, by administering to said mammal an effective amount of a compound of the formula: [R-N(H)N(NO)O-]yX, wherein R is loweralkyl, aryl, arylalkyl, or cycloalkyl, any of which R groups may be optionally substituted by one to three substituents selected from the group consisting of: halo, hydroxyl, al- koxy, amino, amido, carbonyl, carboxyl, or nitro; and wherein X is a biologically acceptable cation, a biologically accept- able metal center, or a biologically acceptable organic group selected from loweralkyl, acyl or amido, and Y is 1 to 3 consist- ent with the valence of X. Pharmaceutical compositions containing the compounds are also provided.

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