C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07C 245/02 (2006.01) C09K 11/07 (2006.01) C12Q 1/68 (2006.01) C09B 31/043 (2006.01) C09B 35/037 (2006.01)
Patent
CA 2720511
The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.
Linvention concerne une nouvelle classe de supports solides pour synthèse doligomères modifiés dacides nucléiques, et des sondes dacide nucléique qui ont un format synthétisé activement sur les nouveaux supports. Des exemples de supports solides comprennent au moins un désactiveur lié par lintermédiaire dun lieur au support solide. Divers exemples de modes de réalisation comprennent un fragment qui stabilise un duplex, triplex ou agrégation dordre supérieur (par exemple hybridation) dacides nucléiques dont loligomère de linvention est un composant. Dautres composants du support solide comprennent des fragments qui stabilisent des agrégations dacides nucléiques, par exemple des intercalateurs, des fragments de liaison de rainure mineurs, des bases modifiées avec un fragment stabilisateur (par exemple des fragments alcynyle et des fragments fluoroalkyle), et des fragments stabilisateurs conformationnels, tels que ceux décrits dans la publication de brevet US no 2007/0 059 752 conjointement détenue.
Cook Ronald M.
Lyttle Matt
Biosearch Technologies Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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