Stabilized oligonucleotides and their use

Details Stabilized oligonucleotides and their use Stabilized oligonucleotides and their use

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2135591

The invention relates to novel stabilized oligonucleotides in which at least one non-terminal pyrimidine nucleoside is modified, and to their use as a diagnostic or pharmaceutical for the treatment of viral infections, cancer or diseases in which integrins or cell-cell adhesion receptors are active.

L'invention porte sur de nouveaux oligonucléotides stabilisés dans lesquels au moins un nucléoside pyrimidine non terminal est modifié, et sur leur utilisation comme agent diagnostique ou produit pharmaceutique pour traiter des infections virales, le cancer ou des maladies dans lesquelles les intégrines ou les récepteurs jouant un rôle dans l'adhésion intercellulaire sont actifs.

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