A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/702 (2006.01) A61K 9/08 (2006.01) A61K 9/19 (2006.01) A61P 19/02 (2006.01) G01N 30/02 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2648578
Various pentosan polysulfate (PPS) formulations useful for treatment of osteoarthritis, interstitial cystitis, and other conditions of mammals are provided. These formulations showed improved resistance to degradation and discoloration and improved stability at physiological pH, even after sterilization. Capillary electrophoresis analysis of these formulations indicates that various formulations remain stable under conditions that caused degradation of PPS in prior art PPS formulations.
La présente invention porte sur diverses formulations de polysulfate de pentosane (PPS) utiles pour le traitement de l'ostéoarthrite, de la cystite interstitielle et d'autres pathologies de mammifères. Ces formulations ont présenté une résistance accrue à la décomposition et à la décoloration et une stabilité améliorée à un pH physiologique, même après stérilisation. L'analyse par électrophorèse capillaire de ces formulations indique que diverses formulations restent stables dans des conditions qui ont provoqué la décomposition de PPS dans les formulations de PPS de l'art antérieur.
Ellinghuysen Jerry A.
Filburn Charles
Griffin David
Henderson Todd R.
Borden Ladner Gervais Llp
Nutramax Laboratories Inc.
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