A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4196 (2006.01) A61K 9/20 (2006.01) A61K 31/4439 (2006.01) A61K 31/675 (2006.01) A61K 47/02 (2006.01) A61K 47/04 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2640331
It is intended to provide a pharmaceutical composition containing an azole compound which is stable and useful as an antifungal drug. According to the invention, the object could be achieved by adding a basic compound such as magnesium carbonate hydroxide, triethylamine or arginine to the azole compound which is unstable to acid. The pharmaceutical composition is stable without causing degradation of the compound even if a condition such as temperature or humidity is changed during production or storage. Further, it is useful as a therapeutic agent for deep mycosis because systemic administration thereof can be achieved by applying it to an oral agent or an injectable agent.
La présente invention concerne une composition pharmaceutique contenant un composé pyrrole stable et utilisable en tant que médicament antifongique. Selon l'invention, cet objectif peut être atteint en ajoutant un composé basique tel qu'un carbonate-hydroxyde de magnésium, une triéthylamine ou une arginine au composé pyrrole qui est instable dans des conditions acides. La composition pharmaceutique est stable sans provoquer la dégradation du composé même dans des conditions dans lesquelles la température ou l'humidité est changée durant la production ou le stockage. En outre, ladite composition pharmaceutique est utilisable en tant qu'agent thérapeutique pour une mycose profonde parce qu'elle peut être administrée de manière systémique en l'appliquant sur un agent oral ou injectable.
Harada Tsutomu
Ishimoto Hayato
Omae Hiroshi
Eisai R&d Management Co. Ltd.
Marks & Clerk
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