Stabilized pharmaceutical composition containing basic...

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01) A61K 31/47 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2500375

This invention provides a stabilized pharmaceutical composition in an oral dosage form comprising a compound of the formula (I) wherein: R11, R10, R5, R6, R7, R8, R1, Y, X, k, p and n are as defined herein, or its pharmaceutically acceptable salts, said pharmaceutical composition containing at least one basic excipient in a concentration sufficient to bring the pH of the composition to at least 8, and at least one pharmaceutically acceptable excipient.

L'invention concerne une composition pharmaceutique stabilisée prête au stockage sous forme de dose orale comprenant un composé représenté par la formule (I). Dans cette formule, R¿11?, R¿10?, R¿5?, R¿ 6?, R¿7?, R¿8?, R, Y, X, k, p et n sont tels que définis dans la description. La composition comprend également des sels de ce composé acceptable sur le plan pharmaceutique ainsi que des esters ou des éthers dudit composé.

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