A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/12 (2006.01) A61K 9/19 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2341568
A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by general formula (I) wherein R1 is a hydrogen atom or an acyl group and R2 and R3 are, the same or different, a hydrogen atom or a hydroxyl group, or a salt thereof and one or more stabilizer(s) selected from the group consisting of a polysaccharide, a disaccharide and sodium chloride.
L'invention concerne une composition pharmaceutique stabilisée sous forme lyophilisée renfermant un composé polypeptidique cyclique de formule générale (I) dans laquelle R?1¿ désigne un atome d'hydrogène ou un groupe acyle et R?2¿ et R?3¿ désignent, qu'ils soient identiques ou différents, un atome d'hydrogène ou un groupe hydroxyle, ou leur sel et un ou plusieurs stabilisateur(s) sélectionné(s) dans le groupe constitué d'un polysaccharide, d'un disaccharide et d'un chlorure de sodium.
Kasai Akihiro
Otomo Kazumi
Sawai Seiji
Astellas Pharma Inc.
Fujisawa Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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