Stabilized pharmaceutical composition of a nonsteroidal...

Details Stabilized pharmaceutical composition of a nonsteroidal... Stabilized pharmaceutical composition of a nonsteroidal...

A - Human Necessities

61

K

A61K 31/557 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/5415 (2006.01) A61K 31/5575 (2006.01) A61K 45/08 (2006.01) A61P 1/04 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2301378

A pharmaceutical composition is provided for the oral administration of an NSAID and a prostaglandin. The composition is a solid dosage form wherein the NSAID is enterically coated and the prostaglandin is present along with an effective stabilizing amount of a prostaglandin stabilizing agent such as hydroxypropyl methylcellulose or polyvinylpyrrolidone. Exemplary dosage forms are bilayer tablets in which the prostaglandin is misoprostol and the NSAID is diclofenac, piroxicam, or a pharmaceutically acceptable salt thereof. Methods for using the composition to treat NSAID-responsive conditions, disorders and diseases are provided as well.

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