A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 9/20 (2006.01) A61K 31/517 (2006.01) A61K 47/00 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2476402
The present invention relates to acid stabilized compositions containing as an active ingredient a quinazolinone derivative, preferably halofuginone or a pharmaceutically acceptable salt of halofuginone. More particularly the present invention relates to use of an acid for improving the stability of a topical, parenteral or oral composition containing quinazolinone derivatives as an active ingredient, preferably halofuginone. Surprisingly, even dry solid tablet dosage forms showed improved stability by addition of an acidic component.
L'invention concerne des compositions stabilisées acides contenant un dérivé de quinazolinone comme principe actif, de préférence de l'halofuginone ou un de ses sels pharmaceutiquement acceptables. L'invention concerne en particulier l'utilisation d'un acide destiné à améliorer la stabilité d'une composition topique, parentérale ou orale contenant des dérivés de quinazolinone comme principe actif, de préférence de l'halofuginone. De manière surprenante, même des formes de dosage en comprimés solides secs présentent une stabilité améliorée grâce à l'addition d'un composant acide.
Yarkoni Shai
Zelikovich Lior
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Collgard Biopharmaceuticals Ltd.
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