A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/133 (2006.01)
Patent
CA 2516399
The present invention provides stable aqueous solutions consisting essentially of: (a) a sphingolipid; (b) lactic acid; and (c) optionally a stabilizing agent; wherein the solution has a molar ratio of lactic acid to sphingolipid of 1:1 to 10:1. The present invention further provides an emulsion formulation consisting essentially of: (a) lactic acid; (b) a sphingolipid, wherein the sphingolipid is present in an amount of about .1 to about 30 mg/ml of emulsion; (b) optionally an isotonic agent; and (c) a phospholipid present in an amount of about 0.2 to about 200 mg/ml of emulsion. Methods of making and using the compositions are also provided.
La présente invention porte sur des solutions aqueuses stables comprenant principalement: <i>(a)</i> un sphingolipide; <i>(b)</i> l'acide lactique et <i>(c)</i> éventuellement un agent stabilisateur. Cette solution a un rapport molaire de l'acide lactique à sphingolipide de 1:1 à 10:1. La présente invention porte également sur une formulation en émulsion comprenant principalement: <i>(a)</i> l'acide lactique; <i>(b)</i> un sphingolipide, le sphingolipide étant présent dans une quantité comprise entre environ 0,1 et environ 30 mg/ml de l'émulsion; <i>(b)</i> éventuellement, un agent isotonique et <i>(c)</i> un phospholipide présent dans une quantité comprise entre environ 0,2 et environ 200 mg/ml de l'émulsion. L'invention porte également sur des procédés de fabrication et d'utilisation de ces compositions.
Gupta Shanker
Maurer Barry James
Reynolds Patrick C.
Vishnuvajjala Rao B.
Childrens Hospital Los Angeles Research Institute
Sim & Mcburney
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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