Stabilized pharmaceutical peptide compositions

Details Stabilized pharmaceutical peptide compositions Stabilized pharmaceutical peptide compositions

A - Human Necessities

61

K

A61K 38/11 (2006.01) A61K 9/00 (2006.01) A61K 38/08 (2006.01) A61K 38/09 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2166296

Disclosed is a stabilized aqueous composition for administration to a patient comprising a biologically active peptide, a buffer, a quaternary amine-type preservative or disinfectant, and an osmotic pressure-controlling agent, which composition can be stored and used at room temperature. The buffer stabilizes the pH of the composition between about 4 and 6. The preferred buffer contains citrate and/or phosphate, and the preferred preservative or disinfectant is benzalkonium chloride. The composition protects the peptide contained therein from adhering to container surfaces, particularly in containers made of polymeric materials.

Composition aqueuse stabilisée pour administration à un patient. Elle comprend un peptide biologiquement actif, un tampon, un désinfectant ou un agent de conservation de type amine quaternaire, ainsi qu'un agent de contrôle de la pression osmotique. Elle peut être mise en réserve et utilisée à la température de la pièce. Le tampon stabilise le pH de la composition entre environ 4 et 6. Le tampon de premier choix contient du citrate et/ou du phosphate, et l'agent de conservation ou le désinfectant privilégié s'avère du chlorure de benzalkonium. La composition permet d'éviter que le peptide qu'elle contient n'adhère aux surfaces de contenant, particulièrement les contenants de polymère.

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