Stabilized picoplatin oral dosage form

Details Stabilized picoplatin oral dosage form Stabilized picoplatin oral dosage form

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2677640

The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt% picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt% of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt% of a lubricant. The dosage form can further include a dispersant.

L'invention concerne une forme posologique orale de picoplatine, médicament anticancéreux, comprenant un noyau et un enrobage, la forme posologique étant exempte de sels métalliques rédox-actifs. Le noyau du comprimé est une poudre sensiblement sèche comprenant environ de 10 à 60 % en poids de picoplatine, le picoplatine étant une matière particulaire présentant un diamètre moyen des particules inférieur à environ 10 microns, environ de 40 à 80 % en poids d'une charge comprenant un hydrate de carbone sensiblement hydrosoluble, hydrodispersable, ou absorbant l'eau, et une quantité efficace s'élevant jusqu'à environ 5 % en poids d'un lubrifiant. La forme posologique peut également comprendre un dispersant.

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