A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5575 (2006.01) A61K 47/14 (2006.01) A61P 15/10 (2006.01)
Patent
CA 2665611
A prostaglandin E composition comprises are substantially free from C1-C4 alcohols and include the prostaglandin E compound together with a (C1-C4)- alkyl (C8-C22) carboxylic ester (e.g., ethyl laurate), an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.
L'invention concerne une composition de prostaglandine E sensiblement exempte d'alcools C1-C4 et contenant un composé de prostaglandine E associé à un ester (C1-C4)-alkyl (C8-C22) carboxylique (du laurate d'éthyle, par exemple), un ester (C4-C18) alkyle (C2-C18) carboxylique N,N-di(C1-C8) alkylamino substitué et/ou un sel d'addition pharmaceutiquement acceptable de ceux-ci et, facultativement, un agent activateur de viscosité, tel que la gomme de guar. La composition selon l'invention peut être combinée à un diluant alcoolique aqueux pour former une composition pharmaceutique à application topique, destinée par exemple au traitement de la dysfonction sexuelle. Ces compositions de prostaglandine E sont stables pendant des périodes de conservation prolongées à température ambiante.
Frank Daniel W.
Wang Yiping
Cassan Maclean
Nexmed Holdings Inc.
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