Stabilized protein crystals, formulations containing them...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/00 (2006.01) A61K 38/22 (2006.01) A61K 38/27 (2006.01) A61K 38/44 (2006.01) A61K 38/45 (2006.01) A61K 38/46 (2006.01) A61K 38/52 (2006.01) A61K 38/53 (2006.01) A61K 39/395 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01) A61K 47/40 (2006.01) B01J 13/12 (2006.01) C12N 9/04 (2006.01) C12N 9/20 (2006.01) C12N 9/86 (2006.01)

Patent

CA 2330476

This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals.

Cette invention concerne des procédés de stabilisation, de stockage et d'apport de macromolécules biologiquement actives telles que des protéines, des peptides de des acides nucléiques. Cette invention concerne en particulier des cristaux de protéines ou d'acide nucléique, ainsi que des formulations et des préparations renfermant lesdits composés. Sont décrits des procédés de cristallisation de protéines et d'acides nucléiques, et de préparation de cristaux de protéines et d'acides nucléiques stabilisés pour des formulations sèches ou en bouillie. La présente invention s'intéresse par ailleurs à l'encapsulation de protéines, de glycoprotéines, d'enzymes, d'anticorps, d'hormones et de cristaux de peptides ou de formulations cristallines sous forme de compositions destinées à des êtres humains ou à des animaux.

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