C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/113 (2006.01) C07K 17/08 (2006.01) C12N 9/78 (2006.01) C12P 21/02 (2006.01) A61K 38/50 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2653061
Methods of stabilizing proteins having at least one oxidizable amino acid thereon, such as recombinant human adenosine deaminase (rhADA) are disclosed. The methods include treating a protein containing an oxidizable amino acid with a sufficient amount of a capping agent such as glutathione under reaction conditions sufficient to cap the oxidizable amino acid without substantially inactivating the protein. Stabilized capped proteins, polymer conjugates of capped proteins, and methods of treatment using the same are also disclosed.
La présente invention porte sur des méthodes de stabilisation de protéines comportant au moins un acide aminé oxydable, telles que l'adénosine désaminase humaine recombinante (rhADA). Les méthodes incluent le traitement d'une protéine contenant un acide aminé oxydable avec une quantité suffisante d'un agent coiffant tel qu'une glutathione dans des conditions réactionnelles suffisantes pour coiffer l'acide aminé oxydable sans inactiver de façon significative la protéine. La présente invention porte également sur des protéines coiffées stabilisées, des conjugués polymères de protéines coiffées et des méthodes de traitement employant lesdites méthodes.
Basu Amartya
Youngster Stephen K.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Enzon Pharmaceuticals Inc.
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