A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)
Patent
CA 2586760
The present invention relates to ramipril compositions with improved stability. More particularly, the present invention is directed to pharmaceutical compositions comprising ramipril that are stabilized against decomposition into degradation products, namely, ramipril-diketopiperazine and ramipril-diacid, during formulation and storage conditions. The present invention also relates to methods for making and methods of manufacturing stabilized ramipril compositions.
La présente invention concerne des compositions de ramipril à la stabilité améliorée. Plus particulièrement, cette invention concerne des compositions pharmaceutiques comprenant du ramipril qui sont stabilisées contre une décomposition en des produits de dégradation, à savoir la ramipril-diketopiperazine et le ramipril-diacide, pendant la préparation et durant les conditions de stockage. Cette invention concerne aussi des procédés de fabrication et de production de ces compositions de ramipril stabilisées.
Beasley Martin W.
Hause David P.
Jolly M.
Sills Kevin H.
Wilson Edward S.
King Pharmaceuticals Research & Development Inc.
Osler Hoskin & Harcourt Llp
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