C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01)
Patent
CA 2505325
The present invention relates to heterospecific polypeptide constructs comprising at least one single domain antibody directed against a therapeutic and/or diagnostic target and at least one single domain antibody directed against a serum protein, said construct having a prolonged lifetime in biological circulatory systems. The invention further relates to methods for stabilising VHHs in biological circulatory systems.
L'invention concerne des produits polypeptidiques hétérospécifiques comprenant au moins un anticorps à domaine unique dirigé contre une cible thérapeutique et/ou diagnostique et au moins un anticorps à domaine unique dirigé contre une protéine sérique, lesdits produits ayant une durée de vie prolongée dans des systèmes circulatoires biologiques. L'invention concerne en outre des procédés permettant de stabiliser les VHH dans des systèmes circulatoires biologiques.
Dreier Torsten
Lauwereys Marc
Silence Karen
Ablynx N.v.
Borden Ladner Gervais Llp
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