Stabilized solid chemical compositions

Details Stabilized solid chemical compositions Stabilized solid chemical compositions

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/47 (2006.01) A61K 31/54 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2049811

Disclosed are stabilized dry chemical (e.g. pharma- ceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group con- sisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble (> 2mg/ml) alkaline stabilizer. The dry composi- tion is relatively more stable than one not containing the water soluble alkaline stabilizer, especially after a high temperature granulation process. The process for preparing the dry composition is also more "rugged" with the added water soluble alkaline stabilizer.

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