Stabilized solid form choline salicylate compositions

Details Stabilized solid form choline salicylate compositions Stabilized solid form choline salicylate compositions

C - Chemistry, Metallurgy

08

B

260/210, 260/590

C08B 11/12 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/015 (2006.01) A61K 31/05 (2006.01) A61K 31/08 (2006.01) A61K 31/14 (2006.01) A61K 31/19 (2006.01) A61K 31/205 (2006.01) A61K 31/235 (2006.01) A61K 31/24 (2006.01) A61K 31/28 (2006.01) A61K 31/575 (2006.01) A61K 31/60 (2006.01) A61K 31/715 (2006.01) C07C 65/10 (2006.01) C07C 69/84 (2006.01) C07C 69/86 (2006.01) C07C 69/88 (2006.01) C07J 9/00 (2006.01) C08B 11/20 (2006.01) C08B 15/00 (2006.01) C08B 15/05 (2006.01) C08B 15

Patent

CA 1070299

ABSTRACT OF THE DISCLOSURE Choline salicylate is stabilized in solid form by means of a metal salicylate having a valence of at least 2, preferably aluminum, bismuth, calcium or magnesium salicylate. The composition is stabilized to a still greater degree by the addition thereto of carboxy-methyl cellulose. A still greater degree of stabilization is achieved by form- ing a complex of the choline salicylate, metal salicylate and carboxy-methyl cellulose. The complex is formed by preparing a solution of the carboxy-methyl cellulose, choline salicylate and metal salicylate, permitting complexing re- action to take place and drying. All of these stabilized forms of choline salicylate are used in solid dosage forms such as granules, tablets, capsules and supporitories for administration to animals and humans, in the course of choline salicylate therapy, to elevate the blood levels of salicylate ion.

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