Stabilized solid forms and method for the production thereof

Details Stabilized solid forms and method for the production thereof Stabilized solid forms and method for the production thereof

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2663941

The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water-soluble drying agent that is selected from the group consisting of trimagnesium dicitrate and/or calcium chloride. The solid medicinal form has a maximum drying loss of 6% and a relative equilibrium moisture content of 25% or less. The invention also relates to solid medicinal forms containing a moisture-sensitive active ingredient and trimagnesium dicitrate.

L'invention concerne des formes galéniques solides comprenant au moins un principe actif et au moins un agent déshydratant hydrosoluble pharmaceutiquement compatible qui est sélectionné dans le groupe comprenant le dicitrate de trimagnésium et/ou le chlorure de calcium. La forme galénique selon l'invention présente une perte au séchage maximale de 6 % et une humidité d'équilibre relative inférieure ou égale à 25 %. Cette invention se rapporte en outre à des formes galéniques solides contenant un principe actif sensible à l'humidité et du dicitrate de trimagnésium.

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