A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/135 (2006.01)
Patent
CA 2094219
ABSTRACT A solid pharmaceutical preparation contains 5 to 50% by weight of ibuprofen and 0.1 to 10% by weight of phenylpropanolamine or a pharmaceutically acceptable salt thereof which are stabilized. The solid pharma- ceutical preparation can be produced by means of granu- lating with carriers at least one active ingredient, preferably both ingredients separately into the ibupro- fen group and the phenylpropanolamine group, and mixing the former with the latter to enhance the stability of the active ingredients. Preferably, in the phenylpro- panolamine group, the amount of any reducing sugar is minimized to such an extent as to maintain the stabili- ty of the active ingredient. The above pharmaceutical preparation is suitable for a cold remedy, which has a more excellent pharmacological activity based on ibu- profen, less decomposability of phenylpropanolamine and less change of external appearance of the preparation due to low compatibility between phenylpropanolamine and ibuprofen. Therefore, the pharmaceutical prepara- tion has longer period of quality assurance.
Kikuta Jun-Ichi
Makino Tadashi
Mizukami Yoshio
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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