Stabilized solid pharmaceutical preparation and method of...

A - Human Necessities – 61 – K

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A61K 47/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/195 (2006.01) A61K 31/47 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2127085

ABSTRACT To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanola- mine. The pharmaceutical preparation may further com- prise ibuprofen. The active ingredients may be further stabilized, in combination with the incorporation of the caffeine, by grouping and incorporating separately each or suitably combined plural of the active ingredi- ents into different groups or by minimizing the amount of any reducing sugar such as lactose. The solid phar- maceutical preparation is practically valuable since decomposition of each active ingredient with the lapse of time is remarkably suppressed and the active ingre- dients are stabilized for a longer period of time.

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