Stabilized soluble glycoprotein trimers

Details Stabilized soluble glycoprotein trimers Stabilized soluble glycoprotein trimers

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/01 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 14/47 (2006.01) C12N 15/49 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2384271

The present application is directed to stabilize HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them - and to identify molecules that interact with specific sites.

L'invention vise à stabiliser les trimères de glycoprotéines de l'enveloppe du VIH. Lesdits trimères sont stabilisés par introduction dans certains sites par exemple dans l'ectodomaine du gp41 de motifs trimériques, de préférence le GCN4 bispiralé ou le domaine trimérique de la fibritine. Ces trimères stabilisés ou les molécules d'ADN codant pour eux peuvent servir à provoquer une réaction immunogène; ils peuvent également servir dans des essais de criblage de molécules interagissant avec eux, et pour identifier des molécules interagissant avec des sites spécifiques.

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