Stabilized solutions of platinum (ii) antitumor agents

Details Stabilized solutions of platinum (ii) antitumor agents Stabilized solutions of platinum (ii) antitumor agents

A - Human Necessities

61

K

A61K 47/12 (2006.01) A61K 31/28 (2006.01) A61K 31/555 (2006.01)

Patent

CA 2128641

Abstract of the Disclosure Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carrier with air or oxygen and, optionally, blanketing the headspace with air or oxygen.

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