Stabilized sustained release composition of bupropion...

A - Human Necessities – 61 – K

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Details

A61K 31/137 (2006.01) A61K 9/14 (2006.01) A61K 47/44 (2006.01) A61P 25/24 (2006.01) A61P 25/34 (2006.01)

Patent

CA 2713365

Disclosed herein is a stabilized sustained release pharmaceutical composition of bupropion hydrochloride and process for preparing the same, wherein said pharmaceutical composition comprising therapeutically effective amount of uncoated fine bupropion hydrochloride and pharmaceutically acceptable adjuvants, and wherein the composition is free of an acidic stabilizer and contains less than about 0.3% by weight of m-chlorobenzoic acid.

L'invention concerne une composition pharmaceutique à libération prolongée stabilisée à base de chlorhydrate de bupropion, ainsi qu'un procédé de préparation de cette composition. Selon l'invention, ladite composition pharmaceutique comprend une quantité thérapeutiquement efficace de chlorhydrate de bupropion fin non enrobé et des adjuvants pharmaceutiquement acceptables, cette composition ne contenant pas de stabilisant acide et contenant moins de 0,3 % en poids approximativement d'acide m-chlorobenzoïque.

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