Stabilized synthetic immunogen delivery system

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/39 (2006.01) A61K 6/00 (2006.01) A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2475102

The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulatory complex is particulate and can efficiently present peptide immunogens to the cells of the immune system to produce an immune response. The immunostimulatory complex may be formulated as a suspension for parenteral administration. The immunostimulatory complex may also be formulated in the form of w/o-emulsions, as a suspension in combination with a mineral salt suspension or with an in-situ gelling polymer for the efficient delivery of an immunogen to the cells of the immune system of a subject following parenteral administration, to produce an immune response which may also be a protective immune response.

la présente invention concerne un complexe immunostimulateur conçu spécifiquement pour agir comme adjuvant et stimulateur immunogène peptidique. Ce complexe immunostimulateur comprend un oligonucléotide CpG et un immunogène peptidique actif biologiquement. De type particulaire, ledit complexe permet de présenter efficacement des immunogènes peptidiques aux cellules du systèmes immunitaires en vue du déclenchement d'une réponse immunitaire. Il peut être préparé sous forme de suspension pour administration parentérale. Ce complexe immunostimulateur peut également se présenter sous forme d'émulsions inverse, de suspension combinée à une suspension de sels minéraux ou avec un polymère gélifiant in situ pour administration efficace d'un immunogène aux cellules du système immunitaire après administration parentérale dans le but de produire une réaction immunitaire de protection.

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