A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/29 (2006.01) A61K 9/08 (2006.01) A61K 9/19 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2314313
A stabilized pharmaceutical composition in the form of a solution for parenteral administration of a parathyroid hormone is described wherein the therapeutically active ingredient is stabilized with a buffer and a polyol. Preferred preparations contain in an aqueous solution human P'TH(1-34), mannitol, an acetate or tartrate buffering agent and m- cresol or benzyl alcohol as a preservative.
L'invention concerne une composition pharmaceutique stabilisée se présentant sous la forme d'une solution, afin de permettre l'administration parentérale d'une parathormone (PTH), le principe actif thérapeutique étant stabilisé au moyen d'un tampon et d'un polyol. Des préparations préférées renferment, dans une solution aqueuse, une PTH(1-34) humaine, du mannitol, un tampon d'acétate ou de tartrate, et du méta-crésol ou un alcool benzylique en tant que conservateur.
Chang Chin-Ming
Havel Henry A.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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