Stabilized therapeutic compositions and formulations

Details Stabilized therapeutic compositions and formulations Stabilized therapeutic compositions and formulations

A - Human Necessities

61

K

A61K 31/568 (2006.01)

Patent

CA 2697160

The invention relates to pharmaceutically acceptable formulations comprising an active pharmaceutical ingredient such as androst-5-ene-3.beta., 17.beta.-diol, androst-5-ene- 3.beta.,7.beta., 17.beta.-triol or derivatives of either of these compounds and an air oxidizable excipient that have been stabilized with respect to efficacy. Use of the efficacy-stabilized formulations to treat a number of conditions or symptoms thereof, such as a symptom associated with exposure to radiation is described.

L'invention concerne des formulations pharmaceutiquement acceptables comprenant un principe pharmaceutique actif tel que androst-5-ène-3ß,17ß-diol, androst-5-ène-3ß,7ß,17ß-triol ou des dérivés de l'un quelconque de ces composés et d'un excipient oxydable à l'air et stabilisées quant à leur efficacité. L'utilisation des formulations stabilisées quant à leur efficacité pour traiter un grand nombre d'affections ou symptômes, tels qu'un symptôme associé à l'exposition à un rayonnement, est décrite.

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