Stabilized viral envelope proteins and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/34 (2006.01) A01N 1/00 (2006.01) A01N 37/18 (2006.01) A61K 38/16 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2370517

This invention provides an isolated nucleic acid which comprises a nucleotide segment having a sequence encoding a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention also provide a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral envelope protein contains one or more mutations in amino acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. This invention further provides methods of treating HIV-1 infection.

La présente invention concerne un acide nucléique isolé qui comprend un segment nucléotidique possédant une séquence codante pour une protéine d'enveloppe virale, laquelle comprend une protéine de surface virale et une protéine transmembranaire virale correspondante. Cette protéine d'enveloppe virale contient une ou plusieurs mutations en séquence d'acides aminés qui renforce la stabilité du complexe formé entre la protéine d'enveloppe virale et une protéine transmembranaire virale correspondante. Cette invention concerne aussi une protéine d'enveloppe virale qui comprend une protéine de surface virale et une protéine transmembranaire virale correspondante. Cette protéine d'enveloppe virale contient une ou plusieurs mutations en séquence d'acides aminées qui renforce la stabilité du complexe formé entre la protéine d'enveloppe virale et la protéine transmembranaire virale. Cette invention concerne aussi des méthodes de traitement de l'infection par le VIH-1.

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