Stabilizers for lyophilized vaccines

Details Stabilizers for lyophilized vaccines Stabilizers for lyophilized vaccines

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 9/00 (2006.01) A61K 39/12 (2006.01) A61K 39/13 (2006.01) A61K 39/165 (2006.01) A61K 39/20 (2006.01) A61K 39/25 (2006.01) A61K 39/29 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2274755

Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increased amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7Ø

L'invention concerne des stabilisants pour vaccins, des formulations de vaccins et des vaccins lyophilisés ayant une stabilité thermique accrue. Les formulations de vaccins comprennent une plus grande quantité d'un alcool polyhydrique à 6 carbones (tel que le sorbitol), une plus grande quantité d'un disaccharide (tel que le sucrose) et une certaine quantité d'un tampon physiologiquement actif destiné à régler le pH sur une valeur comprise entre 6,0 et 7,0 environ.

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