Stable acid labile benzimidazole pharmaceutical compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4439 (2006.01) A61K 9/48 (2006.01) A61K 31/355 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2392353

The present invention relates to a novel oral pharmaceutical stable formulation containing an acid labile benzimidazole compound, which is stabilized with a vitamin E derivative. More specifically, the composition comprises the acid labile benzimidazole compound in solution and/or suspension in oil and/or oil derivatives and a vitamin E derivative as stabilizer. A particular embodiment comprising omeprazole as acid labile benzimidazole compound and vitamin E Polyethylene glycol succinate as vitamin E stabilizer derivative is disclosed.

L'invention concerne une nouvelle formulation pharmaceutique orale stable renfermant un composé benzimidazole labile acide, stabilisé au moyen d'un dérivé de vitamine E. Plus spécialement, la composition renferme le composé benzimidazole labile acide en solution et/ou en suspension dans de l'huile et/ou des dérivés d'huile, et un dérivé de vitamine E comme stabilisateur. Un mode de réalisation particulier comprend l'oméprazole comme composé benzimidazole labile acide et le succinate de polyéthylèneglycol comme dérivé du stabilisateur de vitamine E.

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