Stable aerosol formulation of peptides and protein with...

Details Stable aerosol formulation of peptides and protein with... Stable aerosol formulation of peptides and protein with...

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01) A61K 38/29 (2006.01) A61K 38/44 (2006.01) A61K 38/47 (2006.01) A61K 39/00 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2505810

Glycosidically stabilised macromolecules, such as proteins and peptides, have substantially greater stability in the presence of hydrofluoroalkane propellants for dispensing from metered dose inhalers, when formulated with polyhydroxylated polyalkenes such as PVA.

L'invention concerne des macromolécules glycosidiquement stabilisées, telles que des protéines et des peptides, qui présentent une stabilité sensiblement plus élevée, en présence de propulseurs à hydrofluoroalcane destinés à une administration à partir d'aérosols-doseurs, lorsqu'elles sont formulées avec des polyalcènes polyhydroxylés, tels que le PVAL.

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