Stable amorphous celecoxib composite and process therefor

Details Stable amorphous celecoxib composite and process therefor Stable amorphous celecoxib composite and process therefor

A - Human Necessities

61

K

A61K 31/635 (2006.01) A61K 31/415 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) C07D 231/12 (2006.01)

Patent

CA 2484943

A process is provided for preparing a celecoxib-crystallization inhibitor composite wherein at least a detectable amount of celecoxib is in amorphous form. Also provided are compositions prepared according to such a process. Also provided is a method of treating a medical condition or disorder in a subject where treatment with a cyclooxygenase-2 inhibitor is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount.

L'invention concerne un proc~d~ permettant de pr~parer un composite inhibiteur de cristallisation du celecoxib, au moins une quantit~ d~tectable de celecoxib se pr~sentant sous forme amorphe. L'invention concerne ~galement des compositions pr~par~es ~ partir du proc~d~ pr~cit~. L'invention comprend enfin un proc~d~ permettant de traiter des ~tats ou des troubles pathologiques chez un sujet ~ l'aide d'un inhibiteur de la cyclooxyg~nase-2, ledit proc~d~ consistant ~ administrer, par exemple oralement, la composition de l'invention en quantit~ therapeutiquement efficace.

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