C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2087450
The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a method for producing such a small-loop modified somatotropin. Also provided by the present invention are DNA sequences coding for such small-loop modified somatotropins, plasmids containing such sequences, and organisms containing such plasmids. Furthermore, pharmaceutical compositions including small-loop modified somatotropins and methods for using such pharmaceutical compositions are disclosed.
Auer Henry E.
Rubinelli Peter M.
Seely James E.
Synenki Richard M.
Mallinckrodt Veterinary Inc.
Osler Hoskin & Harcourt Llp
Pitman-Moore Inc.
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