C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2609365
The present invention describes a flexible basestacking monomer that can be incorporated into an oligonucleotide or oligonucleotide analogue, as well as triplex forming oligonucleotides comprising the flexible basestacking monomer. Triplex forming oligonucleotides of the invention are capable of binding sequence specifically to doublestranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
L'invention concerne un monomère souple d'empilement de base pouvant être incorporé dans un oligonucléotide ou un analogue d'oligonucléotide, ainsi que des oligonucléotides formant des triplexes comprenant ledit monomère. Les oligonucléotides formant des triplexes selon l'invention sont capables de lier une séquence de manière spécifique à des acides nucléiques cibles à brin double et sont, par conséquent, intéressants pour la modulation de l'activité d'acides nucléiques cibles et pour la détection d'acides nucléiques cibles.
Filichev Vyachelsav V.
Pedersen Erik Bjerregaard
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Tina Holdings Aps.
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