C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2727992
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
La présente invention concerne des anticorps scFv particulièrement stables et solubles et des fragments Fab spécifiques du TNF, qui comprennent des séquences à chaîne lourde et à chaîne légère spécifiques qui sont optimisées en vue d'obtenir une certaine stabilité, solubilité, la liaison in vitro et in vivo du TNF, et une faible immunogénicité. Lesdits anticorps sont conçus pour le diagnostic et/ou le traitement de troubles à médiation assurée par le TNF. L'invention concerne également des acides nucléiques, vecteurs et cellules hôtes pour l'expression d'anticorps de recombinaison de l'invention, des méthodes pour isoler ceux-ci et l'utilisation desdits anticorps dans le domaine médical.
Borras Leonardo
Gunde Tea
Urech David
Esbatech An Alcon Biomedical Research Unit Llc
Smart & Biggar
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